While doing the quest "The Condition 2" on Ark Ship Episode4. At he point where you need to find a hidden item (Buried USB), might also affect other instances, if you have a full inventory and you don't notice and proceed to " find" the hidden item by interacting with the object, the game does not check if you have enough space in your inventory to carry the item, hence doesn't notify you that you cannot pick the item up or in this case just acquire it, which results in the loss of the item and you not being able to proceed to the next stage of the game, since the portal door to the next stage is not functioning.
Hopefully i described the situation clearly enough, for it to be useful information.